HCID 20698877, compound → HCID 20698876, compound

Participants

Reaction Conditions

Reaction Steps

LiOH monohydrate (29 mg, 0.69 mmol) was dissolved in 1 mL H2O and added to a solution of [4-(2-pyrrolidinone-5-ylcarbonylamino)-2-phenylbenzoyl]methionine methyl ester, prepared as in Example 202A, (108 mg, 0.23 mmol) in 3 mL of THF and the reaction mixture was stirred at 25° C. for 1 hour. The reaction mixture was evaporated and 2 mL of 1N HCl was added to the aqueous residue. The resulting precipitate was filtered and dried under vacuum to give [4-(2-pyrrolidinone-5-ylcarbonylamino)-2-phenylbenzoyl]methionine (96 mg, 91%).

Provenance & Evidence