Hydrochloric Acid → HCID 70213943, compound

Participants

Reaction Steps

To a solution of N-tert-butoxycarbonyl-N-[4-(1-ethylsulfenyl-3-cyclohexylprop-2-ylaminomethyl)-2-(2-methylphenyl)benzoyl]methionine methyl ester (200 mg) in dioxane (1 mL) chilled to its melting point, was added HCl (0.75 mL, 4M in dioxane). After 1 h, the reaction was quenched with excess aqueous sodium bicarbonate, and extracted into dichloromethane. The solution was concentrated, and the residue was purified by silica gel chromatography eluting with 5% methanol/dichloromethane to afford the title compound as a colorless oil (72 mg, 42%). MS (APCI(+)) 587 (M+H)+. MS (APCI(−)) 621 (M+CI)−.

Provenance & Evidence