Butylamine → HCID 18361235, compound

Participants

Reaction Steps

2-Chloroquinoline (500 mg, 3.06 mmol), butylamine (0.90 nrL, 9.16 mmol), and diisopropylethylamine (0.82 mL, 4.58 mmol) were dissolved in acetonitrile (5 mL), and solution refluxed 2 days. Reaction cooled and diluted with EtOAc. Reaction washed with water and brine. Organic layer dried with Na2SO4, filtered, and concentrated in vacuo. Residue purified by flash chromatography on silica gel eluting with 15% EtOAc/Hexanes to afford the desired product as a pale yellow oil (188 mg, 31% ). m/e (DCI) 201 (MH+)

Provenance & Evidence