Butanal → N-[4-(N-Butyl-N-(2-piperidin-1-ylethyl)aminomethyl)-2-(2-methylphenyl)benzoyl]methionine methyl ester
Reaction equation
[CH3:1][O:2][C:3](=[O:35])[C@H:4]([CH2:31][CH2:32][S:33][CH3:34])[NH:5][C:6](=[O:30])[C:7]1[CH:12]=[CH:11][C:10]([CH2:13][NH:14][CH2:15][CH2:16][N:17]2[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]2)=[CH:9][C:8]=1[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[CH3:29].[CH:36](=O)[CH2:37][CH2:38][CH3:39]>>[CH3:1][O:2][C:3](=[O:35])[C@H:4]([CH2:31][CH2:32][S:33][CH3:34])[NH:5][C:6](=[O:30])[C:7]1[CH:12]=[CH:11][C:10]([CH2:13][N:14]([CH2:36][CH2:37][CH2:38][CH3:39])[CH2:15][CH2:16][N:17]2[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22]2)=[CH:9][C:8]=1[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[CH3:29]Participants
3
Procedure
The desired compound was prepared using the method described in Example 403H starting with the compound prepared in Example 1196A and butyraldehyde. m/e (ESI) 552 (MH−)
Sources & evidence
- ORD record
- ord-5d2cc2d5df75420e9848d09f75288b19
- Source dataset
- uspto-grants-2001_10
- Patent number
- US06310095B1
Reaction notes
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