Chloromethyl Methyl Ether → HCID 23116092, compound

Temperature

15 °C

A 47.50 g quantity of ethyldimethylamine (reagent, product of Tokyo Kasei Co., Ltd.) was dissolved in 300 g of dehydrated acetone (reagent, Wako Pure Chemical Ind. Ltd.), followed by replacement with nitrogen. To the solution was added dropwise 52.30 g of chloromethyl methyl ether (reagent, product of Tokyo Kasei Co., Ltd. as purified by distillation) at 5° C. over a period of 1 hour. The mixture was thereafter stirred at a temperature of not higher than 15° C. for 5 hours to terminate the reaction. The reaction mixture was cooled to 5° C., and the resulting solids were filtered off in nitrogen. The filter cake was washed with 150 g of acetone, and thereafter dried in a vacuum, giving 85.90 g of N-ethyl-N-methoxymethyl-N,N-dimethylammonium chloride (white solid).

1. customto terminate
2. customthe reaction
3. temperatureThe reaction mixture was cooled to 5° C.
4. filtrationthe resulting solids were filtered off in nitrogen
5. washThe filter cake was washed with 150 g of acetone
6. customdried in a vacuum

ORD record

ord-ac78dcb3adee44db97ba1c97b495a453

Source dataset

uspto-grants-2013_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08366956B2