Sodium Carbonate → N-methoxymethyl-N-methylpyrrolidinium carbonate

A 1.60 g quantity of sodium carbonate (product of Wako Pure Chemical Ind. Ltd.) was dissolved in 18 g of deionized water, and 5.01 g of N-methoxymethyl-N-methylpyrrolidinium chloride was added to the solution. The mixture was reacted at room temperature for 0.5 hour, whereby the reaction was terminated. The reaction mixture was concentrated and dried in vacuum, and 100 ml of ethyl alcohol was added to the residue to remove insoluble sodium chloride. The resulting product was dissolved in dichloromethane, the solution was filtered with a membrane filter again, and the filtrate was concentrated in a vacuum and dried, giving 5.41 g of the desired product.

1. customThe mixture was reacted at room temperature for 0.5 hour
2. customwhereby the reaction was terminated
3. concentrationThe reaction mixture was concentrated
4. dry with materialdried in vacuum, and 100 ml of ethyl alcohol
5. additionwas added to the residue
6. customto remove insoluble sodium chloride
7. dissolutionThe resulting product was dissolved in dichloromethane
8. filtrationthe solution was filtered with a membrane
9. filtrationfilter again
10. concentrationthe filtrate was concentrated in a vacuum
11. customdried

ORD record

ord-143614ae0ca4455dacc462476a3cf9db

Source dataset

uspto-grants-2013_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08366956B2