Chloromethyl ethyl ether → HCID 23116108, compound
Reaction equation
[CH2:1]([N:4]1[CH2:8][CH2:7][CH2:6][CH2:5]1)[CH2:2][CH3:3].[CH2:9]([O:11][CH2:12][Cl:13])[CH3:10]>CC(C)=O.O>[Cl-:13].[CH2:9]([O:11][CH2:12][N+:4]1([CH2:1][CH2:2][CH3:3])[CH2:8][CH2:7][CH2:6][CH2:5]1)[CH3:10]Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Conditions
- Temperature
- 5 °C
Procedure
A 36.22 g quantity of N-propylpyrrolidine was dissolved in 200 g of dehydrated acetone (up to 0.1% in water content), followed by replacement with nitrogen. To the solution was added dropwise 30.25 g of chloromethyl ethyl ether (reagent, product of Tokyo Kasei Co., Ltd. as purified by distillation) at 5° C. over a period of 1 hour. The mixture was stirred at 5° C. for 5 hours, whereby the reaction was terminated. The reaction mixture was filtered, washed with 100 g of acetone and dried in a vacuum, giving 53.30 g of a white solid product.
Workup
- customwhereby the reaction was terminated
- filtrationThe reaction mixture was filtered
- washwashed with 100 g of acetone
- customdried in a vacuum
Sources & evidence
- ORD record
- ord-8186009aba204de19a938b9221e0ed23
- Source dataset
- uspto-grants-2013_02
- Patent number
- US08366956B2
Reaction notes
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