反应详情

A solution of pyridinium chlorochromate (1.253 g, 5.8 mmol) in 40 mL CH2Cl2 was cooled to 0° C. [4,5-Dimethoxy-2-(1-methyl-2-phenyl-ethyl)-phenyl]-methanol (1.110 g, 3.88 mmol) in 5.0 mL CH2Cl2 was added drop-wise and allowed to stir for 45 minutes. The mixture was diluted in 200 mL Et2O, filtered through celite and concentrated in vacuo to afford a dark brown oil. Purification via flash chromatography (9:1 hexane/ethyl acetate) gave 4,5-dimethoxy-2-(1-methyl-2-phenyl-ethyl)-benzaldehyde (0.840 g, 76%) as a clear oil.

1. additionwas added drop-wise
2. filtrationfiltered through celite and
3. concentrationconcentrated in vacuo
4. customto afford a dark brown oil
5. customPurification via flash chromatography (9:1 hexane/ethyl acetate)