Ethanol → HCID 59359498, compound

HRID 383209Notes

Reaction equation

HRID 383209 reaction equation
[C:1]1([C:7]2[NH:11][C:10]3[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=3[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:16](O)[CH3:17]>>[CH:9]([C:17]1[CH:16]=[CH:3][CH:2]=[CH:1][C:6]=1[N:11]1[C:10]2[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=2[N:8]=[C:7]1[C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)([CH3:15])[CH3:10]

Participants

3

Reactant 2

HCID 702EthanolHCID 128552-Phenylbenzimidazole

Product 1

HCID 59359498HCID 59359498, compound

Procedure

Intermediate 1 (1.5 g, 2.1 mmol) and 142-isopropylphenyl)-2-phenyl-1H-benzo[d]imidazole (2 g, 6.4 mmol) were mixed with 30 ml of ethanol in a three-neck flask under nitrogen. The mixture was heated up to reflux for 24 hours. After cooled to room temperature, the precipitate was collected by filtration. The product was purified by column chromatography using 1:2 dichloromethane and hexanes as eluent. 0.7 g of desired product was obtained after purification.

Workup

  1. temperatureThe mixture was heated up
  2. temperatureto reflux for 24 hours
  3. filtrationthe precipitate was collected by filtration
  4. customThe product was purified by column chromatography

Sources & evidence

ORD record
ord-b99acdb60f3f4cef8075d2903a148c0e
Source dataset
uspto-grants-2013_02
Patent number
US08367223B2

Reaction notes

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