反应详情

To a solution of [4,5-dimethoxy-2-(1-methyl-2-phenyl-ethyl)-phenyl]-(2,4-dimethoxy-pyrimidin-5-yl)-methanol (0.418 g, 0.9 mmol) in 20 mL toluene was added MnO2 (0.335 g, 4.7 mmol). The mixture was warmed to reflux and H2O was removed via a Dean-Stark trap. After 1 hour the mixture was cooled, filtered through a pad of celite and concentrated in vacuo to give a crude oil. Purification via flash chromatography (7:3 hexane/ethyl acetate) afforded [4,5-dimethoxy-2-(1-methyl-2-phenyl-ethyl)-phenyl]-(2,4-dimethoxy-pyrimidin-5-yl)-methanone (0.258 g, 62%) as a clear oil.

1. temperatureThe mixture was warmed
2. temperatureto reflux
3. customH2O was removed via a Dean-Stark trap
4. temperatureAfter 1 hour the mixture was cooled
5. filtrationfiltered through a pad of celite
6. concentrationconcentrated in vacuo
7. customto give a crude oil
8. customPurification via flash chromatography (7:3 hexane/ethyl acetate)