Hydrochloric Acid → HCID 178517704, compound

Participants

Reaction Steps

7-(2-Methoxy-pyridin-3-yl)-3-(2-phenyl-pyridin-4-y1)-imidazo[1,2-a]pyridine (Ex. 1.100) (1 eq, 0.38 mmol, 145 mg) is dissolved in EtOH (0.5 ml) and HCl (37% in H2O, 0.04 eq, 0.015 mmol, 0.5 ml) is added. The reaction is heated at reflux for 3 h and is cooled down to rt before H2O is added. The pH is adjusted to 7 with the addition of NaOH (4N) and the suspension is filtered. The solid is washed with a mixture H2O/EtOH 4:1 and dried in vacuo to afford 3-[3-(2-Phenyl-pyridin-4-yl)-imidazo[1,2-a]pyridin-7-yl]-pyridin-2-ol as a light yellow oil; [M+H]+=365

Provenance & Evidence