3-(2-Phenyl-pyridin-4-yl)-7-(1,2,3,6-tetrahydro-pyridin-4-yl)-imidazo[1,2-a]pyridine → 3-(2-Phenyl-pyridin-4-yl)-7-piperidin-4-yl-imidazo[1,2-a]pyridine

Participants

Reaction Steps

3-(2-Phenyl-pyridin-4-yl)-7-(1,2,3,6-tetrahydro-pyridin-4-yl)-imidazo[1,2-a]pyridine (Ex. 1.190) (1.0 eq, 1.15 mmol, 0.51 g) in dissolved in MeOH (20 ml) and Pd/C (10%, 1.15 eq, 1.32 mmol, 140 mg) and the reaction mixture is hydrogenated at rt for 16 h (4 bar pressure). The solid is removed by filtration and the solvent is evaporated to dryness to yield 3-(2-phenyl-pyridin-4-yl)-7-piperidin-4-yl-imidazo[1,2-a]pyridine as a light yellow solid which did not require any further purification; [M+H]+=391

Provenance & Evidence