反应详情

温度

100 °C

To a solution of 3-bromo-6-bromo-imidazo[1,2-a]pyridine (Intermediate H) (1 eq, 0.72 mmol, 0.2 g), 3-methoxypyrid-4-yl boronic acid (1.0 eq, 0.72 mmol, 0.11 g), Na2CO3 (2 eq, 1.44 mmol, 152 mg) in dioxane (45 ml) and water (13.5 ml) under inert atmosphere of argon is added bis(triphenylphosphine)palladium II chloride (0.1 eq, 0.07 mmol, 50 mg). The reaction mixture is heated at 100° C. for 2 hours. The mixture is diluted with H2O (50 ml) and extracted with EtOAc. The combined organic portions are washed with brine, dried (MgSO4) and concentrated in vacuo. The residue is purified by flash chromatography on silica eluting with 25-75% ethyl acetate in iso-hexane to afford the title compound; [M+H]+=333

1. extractionextracted with EtOAc
2. washThe combined organic portions are washed with brine
3. dry with materialdried (MgSO4)
4. concentrationconcentrated in vacuo
5. customThe residue is purified by flash chromatography on silica eluting with 25-75% ethyl acetate in iso-hexane