Cyclohexanol → HCID 86644337, compound

HRID 383288Notes

Reaction equation

HRID 383288 reaction equation
O1C=CC(C2C=C(C3N4C=C(N[CH:22]5[CH2:27][CH2:26][CH:25]([OH:28])[CH2:24][CH2:23]5)C=CC4=NC=3)C=CN=2)=C1.[Cl:29][C:30]1[CH:35]=[C:34]([C:36]2[N:40]3[CH:41]=[C:42]([NH:45]C4CCC(O)CC4)[CH:43]=[CH:44][C:39]3=[N:38][CH:37]=2)[CH:33]=[CH:32][N:31]=1.[CH:53]1([OH:59])[CH2:58][CH2:57][CH2:56]CC1>>[Cl:29][C:30]1[CH:35]=[C:34]([C:36]2[N:40]3[CH:41]=[C:42]([NH:45][CH:23]4[CH2:22][CH2:27][CH2:26][CH:25]([OH:28])[CH2:24]4)[CH:43]=[CH:44][C:39]3=[N:38][CH:37]=2)[CH:33]=[C:32]([C:57]2[CH:58]=[CH:53][O:59][CH:56]=2)[N:31]=1

Participants

4

Reactant 3

HCID 7966Cyclohexanol2×HCID 252617524-(3-(2-Furan-3-yl-pyridin-4-yl)-imidazo[1,2-a]pyridin-6-ylamino)-cyclohexanolHCID 252619024-[3-(2-Chloro-pyridin-4-yl)-imidazo[1,2-a]pyridin-6-ylamino]-cyclohexanol

Product 1

HCID 86644337HCID 86644337, compound

Procedure

This compound is prepared analogously to 4-(3-(2-furan-3-yl-pyridin-4-yl)-imidazo[1,2-a]pyridin-6-ylamino)-cyclohexanol (Example 2.3) by replacing [4-[3-(2-chloro-pyridin-4-yl)-imidazo[1,2-a]pyridin-6-ylamino]-cyclohexanol (Example 2.1) with 1-(RS/RS)-3-(2,6-dichloro-pyridin-4-yl)-imidazo[1,2-a]pyridin-6-ylamino)-cyclohexanol (Intermediate J); [M+H]+ 409

Sources & evidence

ORD record
ord-6b9ca603a8a649ae9027165ade8d05cc
Source dataset
uspto-grants-2013_02
Patent number
US08367662B2

Reaction notes

Loading…