HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 2-[4-(4-Chlorobenzyl)piperazin-1-yl]ethanethiol dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Thiourea | HCID 2723790 | — |
| Reactant | 1-(4-Chlorobenzyl)-4-(2-chloroethyl)piperazine dihydrochloride | HCID 12362127 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-[4-(4-Chlorobenzyl)piperazin-1-yl]ethanethiol dihydrochloride | HCID 20153173 | 97.8% |
Reaction Steps
The procedure described in Example 1(b) was followed, using 6.1 g of thiourea, 13.8 g of 1-(4-chlorobenzyl)-4-(2-chloroethyl)piperazine dihydrochloride, 4.1 g of triethylamine and 150 ml of reagent ethanol. The hydrolysis was effected with 7.0 g of sodium hydroxide and 50 ml of water. Work-up, as described above, gave 6.7 g (62% of theory) of 2-[4-(4-chlorobenzyl)piperazin-1-yl]ethanethiol dihydrochloride as a white crystalline solid, M.p. 244°-247° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04722926 |
| Source dataset | uspto-grants-1988_02 |
| ORD ID | ord-a44d77395f1c48f3a29b906d95127ca1 |
| Source note | uspto-grants-1988_02 |