(Pyridin-4-yl)boronic acid → 3-Bromo-7-pyridin-4-yl-imidazo[1,2-a]pyridine

HRID 383305Notes

Reaction equation

HRID 383305 reaction equation
[Br:1][C:2]1[N:6]2[CH:7]=[CH:8][C:9]([C:11]3[CH:12]=[C:13](C=[CH:19][CH:20]=3)C(NC)=O)=[CH:10][C:5]2=[N:4][CH:3]=1.[N:21]1C=CC(B(O)O)=CC=1>>[Br:1][C:2]1[N:6]2[CH:7]=[CH:8][C:9]([C:11]3[CH:20]=[CH:19][N:21]=[CH:13][CH:12]=3)=[CH:10][C:5]2=[N:4][CH:3]=1

Participants

3

Reactant 2

HCID 2734379(Pyridin-4-yl)boronic acidHCID 684844313-(3-Bromo-imidazo[1,2-a]pyridine-7-yl)-N-methyl-benzamide

Product 1

HCID 684851173-Bromo-7-pyridin-4-yl-imidazo[1,2-a]pyridine

Procedure

This compound is prepared analogously to 3-(3-Bromo-imidazo[1,2-a]pyridin-7-yl)-N-methyl-benzamide (Intermediate EA) by replacing (3-methylaminocarbonylphenyl)boronic acid (step EA2) with 4-pyridine boronic acid.

Sources & evidence

ORD record
ord-fa15df63510c454f81e578fcd6e60221
Source dataset
uspto-grants-2013_02
Patent number
US08367662B2

Reaction notes

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