反应详情

To a mixture comprising 6-iodo-imidazo[1,2-a]pyridine (1 eq, 95 mmol, 23.3 g) in acetic acid (220 ml) under an inert atmosphere of argon is added dropwise bromine (1 eq, 95 mmol, 4.8 ml). After stirring at room temperature for 1 hour, the reaction mixture is filtered. The resulting solid is suspended in DCM (1% MeOH) (500 ml) and washed with 4N sodium hydroxide (100 ml). When the solid dissolves, the organic layer is separated, dried (MgSO4) and evaporated to give a beige solid; [M+H]+323 (325).

1. filtrationthe reaction mixture is filtered
2. washwashed with 4N sodium hydroxide (100 ml)
3. dissolutionWhen the solid dissolves
4. customthe organic layer is separated
5. dry with materialdried (MgSO4)
6. customevaporated
7. customto give a beige solid