HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromine → 3-Bromo-6-chloroimidazo[1,2-a]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 6-Chloroimidazo(1,2-a)pyridine | HCID 2764328 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 3-Bromo-6-chloroimidazo[1,2-a]pyridine | HCID 45790042 | 109.3% |
Reaction Steps
To 6-chloro-imidazo[1,2-a]pyridine (1 eq, 253 mmol, 39 g) in acetic acid (500 ml) under inert atmosphere, is added dropwise bromine (1 eq, 253 mmol, 13 ml). After 1 hour stirring at room temperature, the reaction mixture is filtered and to give a beige solid (64 g) 3-Bromo-6-chloro-imidazo[1,2-a]pyridine hydrobromide; [M+H]+232 (234)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08367662B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-03eec8a302ca479eb68e62273cc9109a |
| Source note | uspto-grants-2013_02 |