Bromine → 3-Bromo-6-(trifluoromethyl)imidazo[1,2-a]pyridine

HRID 383313Notes

Reaction equation

HRID 383313 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:4]=[CH:5][C:6]2[N:7]([CH:9]=[CH:10][N:11]=2)[CH:8]=1.[Br:14]Br>C(O)(=O)C>[Br:14][C:9]1[N:7]2[CH:8]=[C:3]([C:2]([F:1])([F:12])[F:13])[CH:4]=[CH:5][C:6]2=[N:11][CH:10]=1

Participants

4

Reactant 2

HCID 24408BromineHCID 401480116-(Trifluoromethyl)imidazo[1,2-a]pyridine

Product 1

HCID 455882283-Bromo-6-(trifluoromethyl)imidazo[1,2-a]pyridine

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To 6-trifluoromethyl-imidazo[1,2-a]pyridine (1 eq, 6.2 mmol, 1.1 g) in acetic acid (15 ml) under an inert atmosphere of argon is added dropwise bromine (1 eq, 6.2 mmol, 0.313 ml). After stirring at room temperature for 1 hour, the reaction mixture is filtered to afford the title compound as a beige solid; [M+H]+=266(268)

Workup

  1. filtrationthe reaction mixture is filtered

Sources & evidence

ORD record
ord-0ac4adbf422b4f86acf1b097b950f24c
Source dataset
uspto-grants-2013_02
Patent number
US08367662B2

Reaction notes

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