関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Methyl iodide | HCID 6328 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 4-Chloro-3-isopropylphenol | HCID 18327844 | — |
| 反応物 | 2-Chloro-5-isopropylphenol | HCID 59596487 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 1-Chloro-4-isopropyl-2-methoxybenzene | HCID 58928056 | — |
| 生成物 | 1-Chloro-2-isopropyl-4-methoxy-benzene | HCID 58977025 | — |
反応手順
To a solution of 2-chloro-5-isopropyl-phenol and 4-chloro-3-isopropyl-phenol from step 1 (8.694 g, 47.1 mmol) in 50 mL DMF was added K2CO3. Iodomethane (3.5 mL, 56.5 mmol) was added and the mixture was warmed to 50° C. After 4 hours H2O was added. The mixture was extracted with ethyl acetate, washed with H2O, washed and washed with brine. The combined organic layers were dried over Na2SO4, filtered and concentrated in vacuo to give 1-chloro-4-isopropyl-2-methoxy-benzene and 1-chloro-2-isopropyl-4-methoxy-benzene (9.289 g) as a 7:3 inseparable mixture in the form of a pale yellow oil, which was used directly in the following step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08524725B2 |
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| 出典データセット | uspto-grants-2013_09 |
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| ORD ID | ord-8068116b6197427ab5194e5ca5f86145 |
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| 出典メモ | uspto-grants-2013_09 |
|---|
