2-(2-Isopropyl-4,5-dimethoxy-phenoxy)-3-methoxy-acrylonitrile → HCID 67333774, compound

HRID 38338Notes

Reaction equation

HRID 38338 reaction equation
[CH:1]([C:4]1[CH:16]=[C:15]([O:17][CH3:18])[C:14]([O:19][CH3:20])=[CH:13][C:5]=1[O:6][C:7](=[CH:10]OC)[C:8]#[N:9])([CH3:3])[CH3:2].[S:21]1[CH2:26][CH2:25][CH:24]([NH:27][C:28]([NH2:30])=[NH:29])[CH2:23][CH2:22]1>>[CH:1]([C:4]1[CH:16]=[C:15]([O:17][CH3:18])[C:14]([O:19][CH3:20])=[CH:13][C:5]=1[O:6][C:7]1[C:8]([NH2:9])=[N:29][C:28]([NH:27][CH:24]2[CH2:25][CH2:26][S:21][CH2:22][CH2:23]2)=[N:30][CH:10]=1)([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 670534682-(2-Isopropyl-4,5-dimethoxy-phenoxy)-3-methoxy-acrylonitrileHCID 178512592HCID 178512592, compound

Product 1

HCID 67333774HCID 67333774, compound

Procedure

5-(2-Isopropyl-4,5-dimethoxy-phenoxy)-N2-(tetrahydro-thiopyran-4-yl)-pyrimidine-2,4-diamine was prepared according to the procedure of example 5, using 2-(2-isopropyl-4,5-dimethoxy-phenoxy)-3-methoxy-acrylonitrile (prepared using the procedure of Example 4) together with N-(tetrahydro-thiopyran-4-yl)-guanidine from Preparation 1.

Workup

  1. customprepared
  2. customfrom Preparation 1

Sources & evidence

ORD record
ord-df81bbd53c8c469baff5e451d3d3bb73
Source dataset
uspto-grants-2013_09
Patent number
US08524725B2

Reaction notes

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