Boron tribromide → HCID 44241532, compound

Participants

Reaction Conditions

Reaction Steps

2-Bromo-1-(4-methoxy-phenyl)-1H-indole-3-carbonitrile was dissolved in dry DCM and cooled to 0° C. 5 eq BBr3 (1.0 M solution in hexane) was added and the mixture was stirred over night. Still at 0° C., the reaction was quenched with the addition of MeOH. The mixture was diluted with H2O and the phases were partitioned. The organic phase was concentrated and the crude product purified on silica using n-heptane:EtOAc (4:1) as mobile phase. ES/MS m/z: 313, 315 (M+H), 311, 313 (M−H); 1H NMR (acetone-d6, 500 MHz): 7.69 (m, 1H), 7.38-7.30 (m, 4H) and 7.16-7.10 (m, 3H).

Provenance & Evidence