HCID 58378233, compound → HCID 44466645, compound

Participants

Reaction Steps

1-(2-(3,5-Dimethylisoxazol-4-yl)-1-(4-methoxyphenyl)-1H-indol-3-yl)urea was heated neat in hydriodic acid (aq, 57%) at 100° C. for 3 hours. The reaction mixture was cooled and concentrated, and co-evaporated with DCM and EtOAc. The residue was subjected to reversed phase preparative HPLC. Appropriate fractions were combined and evaporated, and identified by 1H NMR. ES/MS m/z: 363.19 (M+H), 362.18 (M−H); 1H NMR (acetone-d6, 500 MHz): 7.65 (m, 1H), 7.22-7.09 (m, 5H), 6.93 (m, 2H), 2.25 (s, 3H) and 1.94 (s, 3H).

Provenance & Evidence