反应详情

Thionyl chloride (4.02 mL, 55.1 mmol) was added in the dehydrated methanol (100 mL) solution of 4-amino-4-carboxytetrahydro-pyran monohydrochloride (5.00 g, 27.5 mmol) in an ice bath, and the mixture was heated and refluxed for 2.5 hours. The solvent was removed by distillation under reduced pressure, and the obtained crude product was washed with ethyl acetate and then dried under reduced pressure to give a colorless solid (BB04, 5.06 g).

1. temperaturethe mixture was heated
2. temperaturerefluxed for 2.5 hours
3. customThe solvent was removed by distillation under reduced pressure
4. customthe obtained crude product
5. washwas washed with ethyl acetate
6. customdried under reduced pressure
7. customto give a colorless solid (BB04, 5.06 g)