4-(Pyrrolidin-1-yl)phenacyl bromide → HCID 59406739, compound

HRID 383645Notes

Reaction equation

[CH2:1]([O:3][C:4](=[O:23])[NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH2:12][N:13]2[C:18](=[O:19])[CH:17]=[CH:16][C:15]([C:20](=[S:22])[NH2:21])=[N:14]2)[CH:7]=1)[CH3:2].[CH2:24]1[CH2:28][N:27]([C:29]2[CH:34]=[CH:33][C:32]([C:35]([CH2:37]Br)=O)=[CH:31][CH:30]=2)[CH2:26][CH2:25]1>CCO>[CH2:1]([O:3][C:4](=[O:23])[NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH2:12][N:13]2[C:18](=[O:19])[CH:17]=[CH:16][C:15]([C:20]3[S:22][CH:37]=[C:35]([C:32]4[CH:33]=[CH:34][C:29]([N:27]5[CH2:28][CH2:24][CH2:25][CH2:26]5)=[CH:30][CH:31]=4)[N:21]=3)=[N:14]2)[CH:7]=1)[CH3:2]

Participants

Conditions

Temperature: 80 °C

Procedure

104 mg (0.31 mmol) of ethyl[3-(6-oxo-3-thiocarbamoyl-6H-pyridazin-1-yl-methyl)phenyl]carbamate are suspended in 2 ml of EtOH, and 100 mg (0.37 mmol) of α-bromo-4-(1-pyrrolidino)acetophenone are added. The reaction mixture is stirred at 80° C. for 15 h. The precipitate formed is filtered off with suction and washed with ethanol and dried in vacuo.

Workup

customThe precipitate formed
filtrationis filtered off with suction
washwashed with ethanol
customdried in vacuo

Sources & evidence

ORD record: ord-aa239a8cb89b42f0a6711a235c785e39
Source dataset: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08367668B2

Reaction notes

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