HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 383656Generated: October 26, 2026
Piperidine → 5-[[5-(3-chloroanilino)pyrazolo[1,5-a]pyrimidin-3-yl]methylidene]-1-methylimidazolidine-2,4-dione
https://huagongshe.com/reaction/383656
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 1-Methylhydantoin | HCID 69217 | — |
| Reactant | 5-(3-Chlorophenylamino)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde | HCID 58196528 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-[[5-(3-chloroanilino)pyrazolo[1,5-a]pyrimidin-3-yl]methylidene]-1-methylimidazolidine-2,4-dione | HCID 178481635 | — |
Reaction Steps
To 5-(3-chlorophenylamino)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde (20 mg, 0.074 mmol) in 0.5 mL EtOH was added 1-methylimidazolidine-2,4-dione (8.4 mg, 0.074 mmol) and piperidine (7.5 μL, 0.074 mmol). The mixture was heated at 70° C. overnight. The solid formed was isolated by filtration and air dried to give 5-((5-(3-chlorophenylamino)pyrazolo[1,5-a]pyrimidin-3-yl)methylene)-1-methylimidazolidine-2,4-dione. LCMS (M+1=369)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08367681B2 |
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| Source dataset | uspto-grants-2013_02 |
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| ORD ID | ord-dadbdbe654ff4ab896cada5a04f2e7eb |
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| Source note | uspto-grants-2013_02 |
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