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HRID 383660作成日：2026年10月25日
3-(2-Methyl-1H-imidazol-1-yl)aniline → 5-(3-(2-methyl-1H-imidazol-1-yl)phenylamino)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde
https://huagongshe.com/reaction/383660
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 3-(2-Methyl-1H-imidazol-1-yl)aniline | HCID 12797139 | — |
| 反応物 | 5-Chloropyrazolo(1,5-a)pyrimidine-3-carbaldehyde | HCID 58196401 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 5-(3-(2-methyl-1H-imidazol-1-yl)phenylamino)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde | HCID 58196757 | 70.1% |
反応手順
To 5-chloropyrazolo[1,5-a]pyrimidine-3-carbaldehyde (39 mg, 0.215 mmol) in dioxane was added 3-(2-methyl-1H-imidazol-1-yl)aniline (90 mg, 0.520 mmol). The mixture was heated in microwave (200 W) for 50 minutes at 120° C. The solid formed was isolated by filtration and air dried to yield 48 mg 5-(3-(2-methyl-1H-imidazol-1-yl)phenylamino)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde (70% yield). LCMS (M+1=319)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08367681B2 |
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| 出典データセット | uspto-grants-2013_02 |
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| ORD ID | ord-0fb720464be444f1a2d628ab5898e849 |
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| 出典メモ | uspto-grants-2013_02 |
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