HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 383666Generated: October 31, 2026
4-(4-Methylpiperazin-1-yl)aniline → HCID 58196507, compound
https://huagongshe.com/reaction/383666
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-(4-Methylpiperazin-1-yl)aniline | HCID 737253 | — |
| Reactant | 5-Chloropyrazolo(1,5-a)pyrimidine-3-carbaldehyde | HCID 58196401 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 58196507 | HCID 58196507 | — |
Reaction Steps
To 5-chloropyrazolo[1,5-a]pyrimidine-3-carbaldehyde (50 mg, 0.276 mmol) in dioxane was added 4-(4-methylpiperazin-1-yl)aniline (264 mg, 1.381 mmol). The mixture was heated in microwave for 20 minutes at 120° C. The solid formed was isolated by filtration to yield 5-(4-(4-methylpiperazin-1-yl)phenylamino)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde. The residue was used in the next step without further purification. LCMS (M+1=337).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08367681B2 |
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| Source dataset | uspto-grants-2013_02 |
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| ORD ID | ord-0a97e8877f9642d39d54974623874efa |
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| Source note | uspto-grants-2013_02 |
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