HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 383670Generated: October 31, 2026
Water → 5-(3-Chlorophenoxy)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde
https://huagongshe.com/reaction/383670
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 3-Chlorophenol | HCID 7933 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 5-Chloropyrazolo(1,5-a)pyrimidine-3-carbaldehyde | HCID 58196401 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-(3-Chlorophenoxy)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde | HCID 58196625 | 93% |
Reaction Steps
To 5-chloropyrazolo[1,5-a]pyrimidine-3-carbaldehyde (50 mg, 0.276 mmol) in DMF was added 3-chlorophenol (42 mg, 0.331 mmol) and K2CO3 (190 mg, 1.380 mmol). The mixture was heated at 70° C. for several hours. Water was added and the solid formed was isolated by filtration and air dried to yield 70 mg 5-(3-chlorophenoxy)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde as an orange solid (93% yield). LCMS (M+1=274)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08367681B2 |
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| Source dataset | uspto-grants-2013_02 |
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| ORD ID | ord-4376c15c37f34bb993d77bec3b4df967 |
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| Source note | uspto-grants-2013_02 |
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