HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 383675Generated: October 26, 2026
Thiazolidinedione → 5-((5-(4-Methyl-1,4-diazepan-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)methylene)thiazolidine-2,4-dione
https://huagongshe.com/reaction/383675
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thiazolidinedione | HCID 5437 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 5-(4-Methyl-1,4-diazepan-1-yl)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde | HCID 58196399 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-((5-(4-Methyl-1,4-diazepan-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)methylene)thiazolidine-2,4-dione | HCID 75288105 | — |
Reaction Steps
To 5-(4-methyl-1,4-diazepan-1-yl)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde (36 mg, 0.138 mmol) in EtOH was added 2,4-thiazolidinedione (16 mg, 0.138 mmol) and piperidine (14 μL, 0.138 mmol). The mixture was heated at 70° C. and purified by HPLC to yield 5-((5-(4-methyl-1,4-diazepan-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)methylene)thiazolidine-2,4-dione. LCMS (M+1=359)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08367681B2 |
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| Source dataset | uspto-grants-2013_02 |
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| ORD ID | ord-9f5289caca384c719fd2ed67facf6133 |
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| Source note | uspto-grants-2013_02 |
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