Piperidine → HCID 178518474, 화합물

HRID 383679노트

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HRID 383679 반응식
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][O:9][C:10]2[CH:11]=[C:12]([NH:16][C:17]3[CH:22]=[CH:21][N:20]4[N:23]=[CH:24][C:25]([CH:26]=O)=[C:19]4[N:18]=3)[CH:13]=[CH:14][CH:15]=2)[CH2:3][CH2:2]1.[NH:28]1[CH2:34][C:32](=[O:33])[NH:31][C:29]1=[O:30].N1CCCCC1>CCO>[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][O:9][C:10]2[CH:11]=[C:12]([NH:16][C:17]3[CH:22]=[CH:21][N:20]4[N:23]=[CH:24][C:25]([CH:26]=[C:34]5[NH:28][C:29](=[O:30])[NH:31][C:32]5=[O:33])=[C:19]4[N:18]=3)[CH:13]=[CH:14][CH:15]=2)[CH2:3][CH2:2]1

참가 물질

5

반응물 3

HCID 8082PiperidineHCID 10006HydantoinHCID 581966635-(3-(2-Morpholinoethoxy)phenylamino)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde

생성물 1

HCID 178518474HCID 178518474, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

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온도
70 °C

실험 절차

To 5-(3-(2-morpholinoethoxy)phenylamino)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde (81 mg, 0.221 mmol) in EtOH was added hydantoin (27 mg, 0.270 mmol) and piperidine (22 μL, 0.221 mmol). The mixture was heated at 70° C. for 48 hr. The solution was then purified by HPLC to yield 5-((5-(3-(2-morpholinoethoxy)phenylamino)pyrazolo[1,5-a]pyrimidin-3-yl)methylene)imidazolidine-2,4-dione. LCMS (M+1=450)

후처리

  1. customThe solution was then purified by HPLC

출처 및 근거

ORD 기록
ord-3d595355233d4effb555f46cb6b57787
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367681B2

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