Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | Hydantoin | HCID 10006 | — |
| Reactant | 5-(3-Isopropoxyphenylamino)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde | HCID 58196662 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178458403 | HCID 178458403 | — |
Reaction Steps
To 5-(3-isopropoxyphenylamino)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde (80 mg, 0.270 mmol) in EtOH was added hydantoin (27 mg, 0.270 mmol) and piperidine (27 μL, 0.270 mmol). The mixture was heated at 70° C. for several hours. The solid produced was isolated by filtration to yield 5-((5-(3-isopropoxyphenylamino)pyrazolo[1,5-a]pyrimidin-3-yl)methylene)imidazolidine-2,4-dione. LCMS (M+1=379)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08367681B2 |
|---|
| Source dataset | uspto-grants-2013_02 |
|---|
| ORD ID | ord-84181e210c6d4b57ab46096ac7ac5d55 |
|---|
| Source note | uspto-grants-2013_02 |
|---|
