HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 383686Generated: October 26, 2026
3-Chloroaniline → 5-(3-Chlorophenylamino)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde
https://huagongshe.com/reaction/383686
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Chloroaniline | HCID 7932 | — |
| Reactant | 5-Chloropyrazolo(1,5-a)pyrimidine-3-carbaldehyde | HCID 58196401 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 5-(3-Chlorophenylamino)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde | HCID 58196528 | — |
Reaction Steps
To 5-chloropyrazolo[1,5-a]pyrimidine-3-carbaldehyde (120 mg, 0.66 mmol) in 1.5 mL dioxane was added 3-chloroaniline (351 μL, 3.31 mmol). The mixture was heated in microwave 10 minutes at 120° C. The solid formed was isolated by filtration and air dried to give 5-(3-chlorophenylamino)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde as orange solid. LCMS (M+1=273)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08367681B2 |
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| Source dataset | uspto-grants-2013_02 |
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| ORD ID | ord-42781197ba1b41f19dcf8b71354d1c01 |
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| Source note | uspto-grants-2013_02 |
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