HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 383688Generated: October 26, 2026
Thiazolidinedione → HCID 178518469, compound
https://huagongshe.com/reaction/383688
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thiazolidinedione | HCID 5437 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 5-(3-Chlorophenylamino)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde | HCID 58196528 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178518469 | HCID 178518469 | — |
Reaction Steps
To 5-(3-chlorophenylamino)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde (50 mg, 0.184 mmol) in 1 mL EtOH was added 2,4-thiazolidinedione (22 mg, 0.184 mmol) and piperidine (18 μL, 0.184 mmol). The mixture was heated in microwave for 20 minutes at 80° C. The solid formed was isolated by filtration and air dried to give 5-((5-(3-chlorophenylamino)pyrazolo[1,5-a]pyrimidin-3-yl)methylene)thiazolidine-2,4-dione. LCMS (M+1=372)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08367681B2 |
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| Source dataset | uspto-grants-2013_02 |
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| ORD ID | ord-ba4b5c2f56d042c584f4adcf9f271a4a |
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| Source note | uspto-grants-2013_02 |
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