Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | Hydantoin | HCID 10006 | — |
| Reactant | Dichloromethane methanol | HCID 21226129 | — |
| Reactant | HCID 58196499 | HCID 58196499 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178518471 | HCID 178518471 | — |
Reaction Steps
To 5-(3-(morpholinomethyl)phenylamino)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde (56 mg, 0.166 mmol) in EtOH was added hydantoin (16.6 mg, 0.166 mmol) and piperidine (16.8 μL, 0.166 mmol). The mixture was heated at 70° C. overnight. The solid formed was filtered off and filtrated prepared by HPLC then TLC (1% MeOH/DCM) to yield 5-((5-(3-(morpholinomethyl)phenylamino)pyrazolo[1,5-a]pyrimidin-3-yl)methylene)imidazolidine-2,4-dione. LCMS (M+1=420)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08367681B2 |
|---|
| Source dataset | uspto-grants-2013_02 |
|---|
| ORD ID | ord-e0e648db324342b799e78d61bf2232c5 |
|---|
| Source note | uspto-grants-2013_02 |
|---|
