Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | Hydantoin | HCID 10006 | — |
| Reactant | HCID 58196451 | HCID 58196451 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178458500 | HCID 178458500 | — |
Reaction Steps
To 5-(4-isopropoxyphenylamino)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde (70 mg, 0.236 mmol) in EtOH was added hydantoin (23.6 mg, 0.236 mmol) and piperidine (23.9 μL, 0.236 mmol). The mixture was heated at 70° C. overnight. The solid formed was isolated by filtration and air dried to yield 5-((5-(4-isopropoxyphenylamino)pyrazolo[1,5-a]pyrimidin-3-yl)methylene)imidazolidine-2,4-dione. LCMS (M+1=379)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08367681B2 |
|---|
| Source dataset | uspto-grants-2013_02 |
|---|
| ORD ID | ord-0d0d021a8bfb4979a235575ae6514bfd |
|---|
| Source note | uspto-grants-2013_02 |
|---|
