反应详情

To a mixture of 1c (0.364 g, 1.81 mmol) and pyridine (0.158 ml, 2 mmol) in dichloromethane (5 ml) was added tert-butylacetyl chloride (0.242 g, 1.8 mmol). The mixture was stirred at room temperature for 2 hours. The mixture was washed with brine and extracted with ethyl acetate. The organic layer was dried over MgSO4, concentrated and chromatographed to yield 1d (0.361 g, 1.64 mmol, 91%).

1. washThe mixture was washed with brine
2. extractionextracted with ethyl acetate
3. dry with materialThe organic layer was dried over MgSO4
4. concentrationconcentrated
5. customchromatographed