Dimethylformamide dimethyl acetal → HCID 67416039, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1-(2-fluoro-pyridin-4-yl)-3-methyl-butan-2-one (4.8 g, 26.5 mmol) in anhydrous toluene (20 mL) is added N,N-dimethylformamide dimethylacetal (16.0 mL, 120.6 mmol). The reaction is heated at 90° C. for 4 h. The mixture is concentrated in vacuo to give the crude product, 1-dimethylamino-2-(2-fluoro-pyridin-4-yl)-4-methyl-pent-1-en-3-one. The crude product is used as it is.

Provenance & Evidence