2-Methylbenzylamine → HCID 59564751, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-fluoro-4-(5-isopropyl-1H-pyrazol-4-yl)-pyridine (30 mg, 0.15 mmol) in anhydrous DMSO (0.25 mL) is added 2-methyl-benzylamine (37 uL, 0.3 mmol). The reaction mixture is stirred at 150° C. overnight, diluted with EtOAc, and washed with water and brine. The organic layer is dried over sodium sulfate and concentrated in vacuo. The crude product is purified by preparative HPLC to provide 18.8 mg of [4-(5-isopropyl-1H-pyrazol-4-yl)-pyridin-2-yl]-(2-methyl-benzyl)-amine. (Example 1)

Provenance & Evidence