Potassium Phosphate, Tribasic → HCID 86657754, compound

Participants

Reaction Conditions

Reaction Steps

Palladium acetate (8.00 mg, 0.036 mmol) was added to a solution of 4b (210 mg, 0.356 mmol), cyclopropylboronic acid (36.7 mg, 0.427 mmol), tricyclohexylphosphine (20.0 mg, 0.071 mmol) and potassium phosphate tribasic (227 mg, 1.07 mmol) in toluene:water (3.15 mL of an 20:1 mixture, respectively) at rt. The resulting solution was heated to 100° C. After approximately 24 h, the reaction was cooled to rt, diluted with EtOAc and filtered through a short column of Celite®, eluting with EtOAc. The resulting crude residue was purified by column chromatography on silica gel (gradient elution; 0%-1% methanol/EtOAc as eluent) to afford the title compound 4c. m/z (ES) 505 (MH)+.

Provenance & Evidence