反应详情

A solution of methyl 5-hydroxynicotinate (1.50 g) in MeOH (30 ml) was hydrogenated (ca. 4 atm) for 3 days in a Parr low-pressure hydrogenation apparatus with a 5 wt. % Rh on Al2O3 catalyst (300 mg) at 70° C. Rh on Al2O3 catalyst was filtered off and the filtrate was concentrated in vacuo to give the crude methyl cis-5-hydroxypiperidine-3-carboxylate as a pale yellow oil.

1. customfor 3 days
2. customat 70° C
3. filtrationRh on Al2O3 catalyst was filtered off
4. concentrationthe filtrate was concentrated in vacuo