Sodium Hydroxide → HCID 66660145, compound

Participants

Reaction Steps

To the solution of methyl cis-1-[4-methyl-6-(1H-pyrazol-5-ylamino)pyrimidin-2-yl]-5-phenylpiperidine-3-carboxylate trifluoroacetate (34.9 mg) in MeOH (3 ml) was added 2 M aqueous solution of NaOH (1 ml). And the mixture was stirred at room temperature for 1 hour. The mixture was concentrated followed by addition of TFA for neutralization. The residue was purified with preparative RP-HPLC to give cis-1-[4-methyl-6-(1H-pyrazol-5-ylamino)pyrimidin-2-yl]-5-phenylpiperidine-3-carboxylic acid trifluoroacetate (34.9 mg) as a colorless solid.

Provenance & Evidence