Methyl 5-(3-(trifluoromethyl)phenyl)nicotinate → HCID 66660068, compound

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Reaction Steps

A solution of methyl 5-[3-(trifluoromethyl)phenyl]nicotinate (190.1 mg) in MeOH (30 ml) was hydrogenated (ca. 4 atm) for 2 days in a Parr low-pressure hydrogenation apparatus with a 5 wt. % Rh on Al2O3 catalyst (121.6 mg) at 90° C. Rh on Al2O3 catalyst was filtered off and the filtrate was concentrated in vacuo. The residue was purified with silica gel column chromatography (eluent: CHCl3/MeOH=98/2˜90/10) to give methyl cis-5-[3-(trifluoromethyl)phenyl]piperidine-3-carboxylate (71.2 mg) as a pale brown oil.

Provenance & Evidence