2-chloro-6-methyl-N-(1H-pyrazol-3-yl)pyrimidin-4-amine → HCID 178501308, compound

HRID 383794Notes

Reaction equation

HRID 383794 reaction equation
[CH:1]1([C@H:7]2[CH2:12][NH:11][CH2:10][C@@H:9]([C:13]([O:15][CH3:16])=[O:14])[CH2:8]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Cl[C:18]1[N:23]=[C:22]([NH:24][C:25]2[NH:29][N:28]=[C:27]([CH:30]3[CH2:32][CH2:31]3)[CH:26]=2)[CH:21]=[C:20]([CH3:33])[N:19]=1.ClC1N=C(NC2NN=CC=2)C=C(C)N=1>>[CH:1]1([C@H:7]2[CH2:12][N:11]([C:18]3[N:23]=[C:22]([NH:24][C:25]4[NH:29][N:28]=[C:27]([CH:30]5[CH2:32][CH2:31]5)[CH:26]=4)[CH:21]=[C:20]([CH3:33])[N:19]=3)[CH2:10][C@@H:9]([C:13]([O:15][CH3:16])=[O:14])[CH2:8]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 3

HCID 580550402-chloro-6-methyl-N-(1H-pyrazol-3-yl)pyrimidin-4-amineHCID 66660255Methyl cis-5-cyclohexylpiperidine-3-carboxylateHCID 178428184HCID 178428184, compound

Product 1

HCID 178501308HCID 178501308, compound

Procedure

The title compound was prepared by the similar manner described in Example 1 using methyl cis-5-cyclohexylpiperidine-3-carboxylate instead of (S)-3-(tert-butoxycarbonylamino)piperidine, and 2-chloro-N-(3-cyclopropyl-1H-pyrazol-5-yl)-6-methylpyrimidin-4-amine prepared in Referential Example 2 instead of 2-chloro-6-methyl-N-(1H-pyrazol-5-yl)pyrimidin-4-amine.

Sources & evidence

ORD record
ord-edfdf02e257b45bba16c17e92b3c06d5
Source dataset
uspto-grants-2013_02
Patent number
US08367690B2

Reaction notes

Loading…