Methanesulfonyl chloride → HCID 86661362, compound

Participants

Reaction Conditions

Reaction Steps

To the solution of tert-utyl cis-3-cyclohexyl-5-(hydroxymethyl)piperidine-1-carboxylate (431.1 mg) in THF (10 ml) was added TEA (405.0 ml) and MsCl (135.2 ml) at 0° C. After stirring at 0° C. for 1 hour, the insoluble material was filtered off through celite and washed with THF. The filtrate was concentrated to give the crude tert-butyl cis-3-cyclohexyl-5-{[(methylsulfonyl)oxy]methyl}piperidine-1-carboxylate as a pale brown oil.

Provenance & Evidence