1-(Pyridin-2-yl)ethan-1-amine → N-(1-(Pyridin-2-yl)ethyl)-7-(4-(2-(pyridin-2-yl)ethyl)piperazin-1-yl)benzofuran-2-carboxamide
Reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][N:9]1[CH2:14][CH2:13][N:12]([C:15]2[C:23]3[O:22][C:21]([C:24]([O-:26])=O)=[CH:20][C:19]=3[CH:18]=[CH:17][CH:16]=2)[CH2:11][CH2:10]1.[Li+].[N:28]1[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=1[CH:34]([NH2:36])[CH3:35]>>[N:28]1[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=1[CH:34]([NH:36][C:24]([C:21]1[O:22][C:23]2[C:15]([N:12]3[CH2:13][CH2:14][N:9]([CH2:8][CH2:7][C:2]4[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=4)[CH2:10][CH2:11]3)=[CH:16][CH:17]=[CH:18][C:19]=2[CH:20]=1)=[O:26])[CH3:35]Participants
3
Procedure
The compound was prepared according to the procedure disclosed in Example 1 starting from lithium 7-(4-(2-(pyridin-2-yl)ethyl)piperazin-1-yl)benzofuran-2-carboxylate (60 mg, 0.16 mmol) and 1-(pyridin-2-yl)ethanamine (23 mg, 0.19 mmol). Yield: 20 mg (25%).
Workup
- customThe compound was prepared
Sources & evidence
- ORD record
- ord-009e50ccc46744b29c1c351d7f1239c0
- Source dataset
- uspto-grants-2013_02
- Patent number
- US08367676B2
Reaction notes
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