1-(3-Chloropyridin-2-YL)piperidin-4-amine → N-(1-(3-Chloropyridin-2-yl)piperidin-4-yl)-7-(4-(2-(pyridin-2-yl)ethyl)piperazin-1-yl)benzofuran-2-carboxamide

HRID 383810Notes

Reaction equation

HRID 383810 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][N:9]1[CH2:14][CH2:13][N:12]([C:15]2[C:23]3[O:22][C:21]([C:24]([O-:26])=O)=[CH:20][C:19]=3[CH:18]=[CH:17][CH:16]=2)[CH2:11][CH2:10]1.[Li+].[Cl:28][C:29]1[C:30]([N:35]2[CH2:40][CH2:39][CH:38]([NH2:41])[CH2:37][CH2:36]2)=[N:31][CH:32]=[CH:33][CH:34]=1>>[Cl:28][C:29]1[C:30]([N:35]2[CH2:40][CH2:39][CH:38]([NH:41][C:24]([C:21]3[O:22][C:23]4[C:15]([N:12]5[CH2:11][CH2:10][N:9]([CH2:8][CH2:7][C:2]6[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=6)[CH2:14][CH2:13]5)=[CH:16][CH:17]=[CH:18][C:19]=4[CH:20]=3)=[O:26])[CH2:37][CH2:36]2)=[N:31][CH:32]=[CH:33][CH:34]=1

Participants

3

Reactant 2

HCID 127601081-(3-Chloropyridin-2-YL)piperidin-4-amineHCID 68787401Lithium 7-(4-(2-(pyridin-2-yl)ethyl)piperazin-1-yl)benzofuran-2-carboxylate

Product 1

HCID 59636728N-(1-(3-Chloropyridin-2-yl)piperidin-4-yl)-7-(4-(2-(pyridin-2-yl)ethyl)piperazin-1-yl)benzofuran-2-carboxamide

Procedure

The compound was prepared according to the procedure disclosed in Example 1 starting from lithium 7-(4-(2-(pyridin-2-yl)ethyl)piperazin-1-yl)benzofuran-2-carboxylate (80 mg, 0.21 mmol) and 1-(3-chloropyridin-2-yl)piperidin-4-amine (57 mg, 0.27 mmol). Yield: 50 mg (40%).

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-dd971f1cc823440fa0bdbdb5af2e5b20
Source dataset
uspto-grants-2013_02
Patent number
US08367676B2

Reaction notes

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