反应详情

Sodium borohydride (1.3 g, 34.8 mmol) was added to a solution of ethyl 2-(6-methoxypyridin-2-yl)acetate (0.68 g, 3.48 mmol) in ethanol (20 mL). The resulting solution was stirred at room temperature over night. The solvent was removed in vacuo. Ethyl acetate and saturated NaHCO3 solution were added. The organic layer was separated and the aqueous layer was extracted with ethyl acetate. The combined organic layers were dried (Na2SO4) and concentrated to give the product. Yield: 0.23 g (44%).

1. customThe solvent was removed in vacuo
2. additionEthyl acetate and saturated NaHCO3 solution were added
3. customThe organic layer was separated
4. extractionthe aqueous layer was extracted with ethyl acetate
5. dry with materialThe combined organic layers were dried (Na2SO4)
6. concentrationconcentrated
7. customto give the product