HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 383844Generated: October 26, 2026
Triethylsilane → 1-(5-(2-Bromoethyl)indolin-1-yl)ethanone
https://huagongshe.com/reaction/383844
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylsilane | HCID 12052 | — |
| Reactant | 1-(1-acetyl-2,3-dihydro-1H-indol-5-yl)-2-bromoethanone | HCID 19711329 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | 1-(5-(2-Bromoethyl)indolin-1-yl)ethanone | HCID 51713236 | — |
Reaction Steps
Triethylsilane (8.8 mL, 54.9 mmol) was added to a solution of 1-(1-acetylindolin-5-yl)-2-bromo-ethanone (1.9 g, 6.73 mmol) in trifluoroacetic acid (70 mL) at rt. The mixture was heated at 55° C. for 18 h, then cooled and concentrated under reduced pressure. The product was purified by flash chromatography (SiO2; hexane/EtOAc; 75/25). Yield: 1.2 g (67%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08367676B2 |
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| Source dataset | uspto-grants-2013_02 |
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| ORD ID | ord-11716dfe03da494298172d49b155e09f |
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| Source note | uspto-grants-2013_02 |
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