HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → 5-Fluoro-N,N-dimethyl-7-(4-(2-(pyridin-2-yl)ethyl)piperazin-1-yl)benzofuran-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-(2-Bromoethyl)pyridine | HCID 12913858 | — |
| Reactant | 5-fluoro-N,N-dimethyl-7-(piperazin-1-yl)benzofuran-2-carboxamide | HCID 59636725 | — |
| Product | 5-Fluoro-N,N-dimethyl-7-(4-(2-(pyridin-2-yl)ethyl)piperazin-1-yl)benzofuran-2-carboxamide | HCID 59636734 | — |
Reaction Steps
A reaction mixture of 5-fluoro-N,N-dimethyl-7-(piperazin-1-yl)benzofuran-2-carboxamide (0.10 g, 0.35 mmol), 2-(2-bromoethyl)pyridine:HBr (0.132 g, 0.49 mmol) and triethylamine (0.12 mL, 0.88 mmol) was heated at 80° C. over night. The product was purified by preparative HPLC to give the title compound. Yield: 0.091 g (65%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08367676B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-b7dec469b6f1415496db1ae6d27eff3e |
| Source note | uspto-grants-2013_02 |